Here's my best attempt
4 A's
Choose any 4 of 6 positions for the A's = C (6,4)
For the other two positions we can choose 1 of 25 remaining letters for one position and then 1 of any 24 remaining letters (We can't choose 2 B's )
So
C(6,4) * 25 * 24 = 9000
2 B's
Choose any 2 of 6 positions for the B's
For the other positions we can choose any 1 of 25 letters for 1 position and (24)^3 for the other 3 positions ( we can't have 2 A's)
C(6,2) * 25 * 24^3 = 5,184,000
4A;s, 2B's = All the arrangements for the "word" AAAABB = 6! / ( 4! * 2!) = 15
I get
9000 + 5,184,000 + 9000 = 5,202,000 plates